CD45 抗原

CD45分子为单链内在膜蛋白,至少有5种亚型,范围为180-220kDa。它们是由基因组序列的3个外显子( A BC选择性剪接组合产生的。非限制性CD45抗原,白细胞共同抗原(LCA)包括细胞外序列,位于细胞膜近端,这对所有CD45亚型都很常见。所有属于CD45簇的单克隆抗体均与抗原该部分反应,能够识别所有CD45亚型。这些亚型具有胞浆外序列,序列长度为 391552个氨基酸残基,具有大量的N连接碳水化合物附着位点。胞浆部分包含2个磷酸酪氨酸-磷酸酶域。非限制性CD45抗原表位存在于所有人白细胞、淋巴细胞、嗜酸性粒细胞单核细胞、嗜碱性粒细胞和中性粒细胞的表面,表达水平依次降低。CD45 是淋巴细胞细胞膜的主要成分。红细胞和血小板中不含CD45。它在骨髓红系细胞成熟过程中消失。CD45抗体与骨髓中的白细胞祖细胞反应。J33单克隆抗体可与人白细胞上存在的所有CD45亚型结合。


Clone: KC56 (T-200) Isotype: IgG1 Mouse

Clone: ALB12 Isotype: IgG1 Mouse

The ALB12 antibody recognizes a carbohydrate epitope and should not be used for side scatter versus CD45 gating strategy in flow cytometry.

Clone: Immu19.2 Isotype: IgG1 Mouse

Clone: J33 Isotype: IgG1 Mouse

J33 was assigned to CD45 cluster in HLDA 3 under the name I-33 (antibody # 818).

选择 CD45 型号

Content and Resources

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