Echo 650 Plus Series Acoustic Liquid Handlers
High‑Throughput, Non‑Contact, Accurate, and Precise Liquid Dispensing with Volumes as Low as 2.5 nL
Building on the trusted foundation of the legacy Echo 650 Series, the new Echo 650 Plus Series elevates acoustic liquid handling with machine‑learning–powered accuracy, a Next Generation Transducer featuring a titanium lens for unmatched stability and advanced electronics that deliver significantly faster real-time computation with dramatically lower power consumption.
Echo 650 Plus Series Key Features and Benefits
Key Features
- Uses acoustic liquid handling technology to move a wide range of liquids (including DMSO‑based) with sound waves, without physical contact
- Delivers accurate, precise, high‑throughput (up to 700 drops/sec) liquid transfer of nanoliter‑scale quantities as low as 2.5 nL
- Enables complex “any source well to any destination well” combinatorial transfers
- Transfers liquids from 384 well and 1,536 well Echo Qualified microplates, as well as sample tubes* arrayed in a 96-tube format
- Dispenses into any ANSI/SLAS‑compliant dry or pre‑filled 96‑, 384‑, and 1,536‑well microplates (8–16 mm height), as well as select non‑compliant labware
- Supports direct dilution of samples and reagents, including compounds
- Features dynamic machine-learning tools that analyze liquid and plastic characteristics (e.g., DMSO hydration level) and adjust sound‑pulse parameters for optimal transfer quality
- Integrates with other liquid handlers and robotic systems
Key Benefits
- Minimizes compound loss, cross-contamination, carryover, or leachates
- Enables assay miniaturization with no loss of data quality
- Reduces reagent costs, plastic waste, and the use of hazardous liquids, while conserving precious samples
- Generates dose‑response and standard curves free from errors commonly introduced by tip‑based liquid handlers and serial dilution
- Accelerates execution of highly complex, multi‑component assays and experiments
- Enables fully automated custom non-contact liquid handling workflows, including sample transfer from sample storage all the way to assay-ready plates
- Supports ultra-high-density sample storage, preserves sample integrity from storage to screen and rapidly pick sets of samples for targeted screening when using acoustic sample tubes*
*Available for tube-enabled models
Echo 650 Plus Series Applications
The Echo 650 Plus Series Acoustic Liquid Handlers, like their predecessors, are designed to be used in pharmaceutical and biotech R&D for:
- High-Throughput Screening (HTS)
- Reiterative hybrid deep learning–wet lab screening (OOD discovery)
- Sample Management
- Synthesis-to-Screening (S2S)
- Direct-to-Biology (D2B)
- Assay Development
- Combination/synergistic screens
- Pooled perturbations
- Arrayed functional genomics screens (siRNA/sgRNA/RNP)
Didn't find the application needed? Talk to our expert.
Echo 650 Plus Series Key Enhancements
Extending the proven performance of the Echo 650 Series, the Echo 650 Plus Series Acoustic Liquid Handlers introduce a new level of reliability, stability and usability:
Next Generation Transducer (NGT)
Features a custom‑designed titanium focal lens and is engineered to resist water intrusion and remain stable even after dry‑out events. It maintains consistent performance over time without the need for periodic Gain, Power, or Focal Sweep adjustments.
Next Generation Core Electronics
Delivers significantly faster real-time computation while consuming 54% less power than the legacy Echo 650 Series. This combination of speed and energy efficiency enhances overall system performance and reduces operational costs.
Dynamic Fluid Analysis 2 (DFA2) : DFA Plus New DPA and DMA
Reinforcing the well-known DFA, the new machine-learning-based Dynamic Plastic Analysis (DPA)* and Dynamic Mound Analysis (DMA)* correct for manufacturing variability across source plates and select optimal sub-calibrations for each transfer well. The result is more accurate, precise and consistent Acoustic Droplet Ejection (ADE).
*Plate and calibration-dependent
BeckmanConnect Remote Support Tool
Enables secure remote access for our certified engineers to quickly diagnose, troubleshoot, and resolve system issues without the need for an on‑site visit. This enhancement minimizes downtime, accelerates issue resolution, and helps maximize laboratory productivity. Learn more →
Echo 650 Plus Series Specifications
| Drop Transfer Resolution | 2.5 nL |
| Technology | Acoustic Droplet Ejection (ADE), Dynamic Fluid Analysis 2 (DFA2), Next Generation Transducer (NGT) |
| Throughput | Ideal for medium- to high-throughput acoustic liquid handling workflows |
| Liquid Class Calibration | Not needed |
| Compatible Source Labware | Echo Qualified 384-well Low Dead Volume (384LDV) Source Microplates, Echo Qualified 384-well Polypropylene (384PP) Source Microplates, Echo Qualified 1,536-well Low Dead Volume (1536LDV) Source Microplates, Acoustic Sample Tubes* |
| Compatible Destination Labware | Most ANSI/SLAS-compliant microplates in 96-well, 384-well and 1,536-well-format that are 8–16 mm in height. Non-compliant labware (e.g. microscope slides) may be supported with a customer-supplied labware holder. |
| Compatible Liquid Types | Simple buffers (e.g. PBS), cell culture media, aqueous solutions containing DNA (sheared DNA, cDNA, plasmids, gene fragments), RNA (mRNA, gRNA, sgRNA), proteins (enzymes, antibodies) and RNPs, serum, plasma, aqueous reagents and solutions containing surfactants, primers/probes, up to 50% glycerol solutions, 70–100% DMSO, crystallography reagents (MPD, PEGS, osmotic solutions), alcohol solutions** |
| Software | Echo Client Utility (Included) | Optional Echo Software Applications 1.8.X : Echo Plate Reformat, Echo Cherry Pick, Echo Dose-Response, Echo Combination Screen, Echo Plate Audit, Echo Array Maker |
| Power Requirements | 100–230 VAC, 5 A, 50/60 Hz |
| Ambient Temperature Range | 16°C– 26°C (61°F–79°F) |
| Humidity Restrictions | 10–80% (non-condensing) |
| Maximum Noise Output | 66 dBA |
| Dimensions | Width: 53.8 cm (21.2 in) Depth: 74.6 cm (29.3 in) Height: 91.5 cm (36.0 in) |
| Vacuum Requirements | Option 1: House supply minimum 200 Torr (266 mbar, 22 inches Hg Vac) | Option 2: Standalone vacuum with surge tank (10 L), minimum pump speed 2.0 m^3/hr (70.68 ft^3/hr), minimum pressure 100 Torr (133 mbar, 26 inches Hg Vac) |
| Max Altitude | Up to 2,000 m (6,562 ft) |
| Weight | 117 kg (258 lbs) |
| Client PC Operating System | Windows® 11 |
| Operating Modes | Standalone or Integrated |
*Only the Echo 650T Plus and Echo 655T Plus models are compatible with the Acoustic Sample Tubes from Azenta Life Sciences. The Echo 650 Plus and Echo 655 Plus models are upgradable to the Echo 650T Plus and Echo 655T Plus models.
**Liquid compatibility varies by source plate type as well as other factors, including but not limited to sample viscosity, solute concentrations and acoustic impedance.
Integrated Systems for Workflow Automation
To meet the broad spectrum of sample throughput needs, Echo 650 Plus Series Liquid Handlers seamlessly integrate with the highly configurable Access Laboratory Workstation and Access Single/Dual Robot Systems accommodating a wide variety of devices and enabling a fully automated workflow.
- Configured to achieve optimal throughput for sample management and screening workflows
- Compact and ergonomic design with docking modules, turntables, retractable shelves, and enclosure doors
- Optional features can include HEPA or environmental integration to protect samples from contamination, hydration or evaporation
Echo 650 Plus Series Service Support
The Echo 650 Plus Series is built for performance, and your service plan ensures your investment is protected, maximizing uptime so your workflows continue to move forward. With a service plan from Beckman Coulter Life Sciences you get:
- Certified OEM Parts
- Expert Engineer Support
- Priority Response
- Software and Hardware Updates
- Predictable Cost Control
- Comprehensive Remote and Onsite Support
- OEM Compliance
Need more information? Visit our Service Plan Webpage to learn more.
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Echo Qualified Consumables Compatible with Echo 650 Plus Series
Echo® Qualified 384-Well Polypropylene Microplate, Clear, Non-sterile
Echo® Qulified 384-Well Polypropylene (PP) Source Microplates ensure accurate and precise transfer with the Echo® Liquid Handler. This microplate is highly rsistant to solvents including DMSO and buffers making it ideal for compound and sample storage.
Echo® Qualified 384-Well Polypropylene Microplate, Clear, Sterile
Echo® Qulified 384-Well Polypropylene (PP) Source Microplates ensure accurate and precise transfer with the Echo® Liquid Handler. This microplate is highly rsistant to solvents including DMSO and buffers making it ideal for compound and sample storage.
Echo(R) Qualified 384-Well Polypropylene Microplate, Clear, Non-sterile, Barcoded
Echo® Qulified 384-Well Polypropylene (PP) Source Microplates ensure accurate and precise transfer with the Echo® Liquid Handler. This microplate is highly rsistant to solvents including DMSO and buffers making it ideal for compound and sample storage.
Echo® Qualified 384-well Cyclic Olefin Copolymer (COC) Source Microplate, Low Dead Volume, Clear, Non-sterile
Echo® Qualified 384-Well Low Dead Volume (LDV) Source Microplates are designed to minimize dead volume when using the Echo® Liquid Handler. This microplate is constructed of Cyclic Olefin Copolymer (COC) for optimal acoustic transfer performanceand DMSO storage. Each lot of microplates is tested and certified to meet stringent performance specifications.
The 384-Well Low Dead Volume (LDV) plate is designed to minimize dead volume when using the Echo® liquid handling system. This microplate is constructed of Cyclic Olefin Copolymer (COC) for optimal acoustic transfer performance and DMSO storage. Each lot of microplates is tested and certified to meet stringent performance specifications. Additional benefits of the microplate include: compatibility with heat sealing devices, designed for barcode customization and optimized for robotic handling.
Precise Manufacturing for Superior Results
For best results, Echo Liquid Handlers are designed to use Echo Qualified 384-well and 1536-well Source Microplates for precise and accurate liquid transfer.
Echo Qualified Microplates deliver the best possible results in compound storage and miniaturized assays, and each plate is insured to meet the specifications required for consistent acoustic transfers. Labcyte performs functional qualification tests on each microplate lot with an Echo Liquid Handler to verify that our microplates deliver superior precision and accuracy and DMSO hydration measurements.
Echo® Qualified 384-well Cyclic Olefin Copolymer (COC) Source Microplate, Low Dead Volume, Clear, Sterile
Echo® Qualified 384-Well Low Dead Volume (LDV) Source Microplates are designed to minimize dead volume when using the Echo® Liquid Handler. This microplate is constructed of Cyclic Olefin Copolymer (COC) for optimal acoustic transfer performanceand DMSO storage. Each lot of microplates is tested and certified to meet stringent performance specifications.
The 384-Well Low Dead Volume (LDV) plate is designed to minimize dead volume when using the Echo® liquid handling system. This microplate is constructed of Cyclic Olefin Copolymer (COC) for optimal acoustic transfer performance and DMSO storage. Each lot of microplates is tested and certified to meet stringent performance specifications. Additional benefits of the microplate include: compatibility with heat sealing devices, designed for barcode customization and optimized for robotic handling.
Precise Manufacturing for Superior Results
For best results, Echo Liquid Handlers are designed to use Echo Qualified 384-well and 1536-well Source Microplates for precise and accurate liquid transfer.
Echo Qualified Microplates deliver the best possible results in compound storage and miniaturized assays, and each plate is insured to meet the specifications required for consistent acoustic transfers. Labcyte performs functional qualification tests on each microplate lot with an Echo Liquid Handler to verify that our microplates deliver superior precision and accuracy and DMSO hydration measurements.
Echo(R) Qualified 384-well Cyclic Olefin Copolymer (COC) Source Microplate, Low Dead Volume, Clear, Non-sterile, Barcoded
Echo® Qualified 384-Well Low Dead Volume (LDV) Source Microplates are designed to minimize dead volume when using the Echo® Liquid Handler. This microplate is constructed of Cyclic Olefin Copolymer (COC) for optimal acoustic transfer performanceand DMSO storage. Each lot of microplates is tested and certified to meet stringent performance specifications.
The 384-Well Low Dead Volume (LDV) plate is designed to minimize dead volume when using the Echo® liquid handling system. This microplate is constructed of Cyclic Olefin Copolymer (COC) for optimal acoustic transfer performance and DMSO storage. Each lot of microplates is tested and certified to meet stringent performance specifications. Additional benefits of the microplate include: compatibility with heat sealing devices, designed for barcode customization and optimized for robotic handling.
Precise Manufacturing for Superior Results
For best results, Echo Liquid Handlers are designed to use Echo Qualified 384-well and 1536-well Source Microplates for precise and accurate liquid transfer.
Echo Qualified Microplates deliver the best possible results in compound storage and miniaturized assays, and each plate is insured to meet the specifications required for consistent acoustic transfers. Labcyte performs functional qualification tests on each microplate lot with an Echo Liquid Handler to verify that our microplates deliver superior precision and accuracy and DMSO hydration measurements.
Echo® Qualified 1536-well Cyclic Olefin Copolymer (COC) Source Microplate, Low Dead Volume, Clear, Non-sterile
The 1536-Well Low Dead Volume (LDV) plate
improves assay results by increasing working range
and reducing dead volume. This microplate is
constructed with exceptional bottom flatness and
of Cyclic Olefin Copolymer (COC), which provides
optical clarity and improved signal levels for
luminescence and flourescence-based assays. Each
lot of plates is tested and certified to meet stringent
performance specifications to ensure lot to lot
consistency
Echo® Qualified 1536-well Cyclic Olefin Copolymer (COC) Source Microplate, Low Dead Volume, Clear, Sterile
The 1536-Well Low Dead Volume (LDV) plate
improves assay results by increasing working range
and reducing dead volume. This microplate is
constructed with exceptional bottom flatness and
of Cyclic Olefin Copolymer (COC), which provides
optical clarity and improved signal levels for
luminescence and flourescence-based assays. Each
lot of plates is tested and certified to meet stringent
performance specifications to ensure lot to lot
consistency
Echo(R) Qualified 1536-well Cyclic Olefin Copolymer (COC) Source Microplate, Low Dead Volume, Clear, Non-sterile, Barcoded
The 1536-Well Low Dead Volume (LDV) plate
improves assay results by increasing working range
and reducing dead volume. This microplate is
constructed with exceptional bottom flatness and
of Cyclic Olefin Copolymer (COC), which provides
optical clarity and improved signal levels for
luminescence and flourescence-based assays. Each
lot of plates is tested and certified to meet stringent
performance specifications to ensure lot to lot
consistency
MicroClime® Environmental Lid
The MicroClime® Environmental Lid minimizes edge
effects and preserves the concentrations of solutions
in microplate wells. The MicroClime® Environmental
Lid incorporates a unique, fluid-absorbing matrix
that creates a vapor barrier, protecting the sample
from the exterior environment from evaporation or
hydration and greatly reducing edge effects. The
MicroClime Environmental Lid does not require any
specialized tools and is compatible with robotic plate
lidding and delidding systems.
Increase Microplate Efficiency Up to 37%
MicroClime Lids enable you to use all the wells in your microplate, from edge to center. This can increase your microplate productivity by up to 37%. They also eliminate damaging edge effects which may occur due to long-term cell incubation. They are compatible with a wide variety of SBS-standard microplates.
Minimize edge effects and preserves the concentrations of solutions in microplate wells. MicroClime Lids incorporate a unique, fluid-absorbing matrix. The absorbed fluid creates a vapor barrier that protects the sample from the exterior environment, especially near the edges of the microplate. Compatible with robotic plate lidding systems, and they can be filled with a variety of fluids, using either a hand-held syringe or automated bulk fillers.
MicroClime® Environmental Lid, Sterile
The MicroClime® Environmental Lid minimizes edge
effects and preserves the concentrations of solutions
in microplate wells. The MicroClime® Environmental
Lid incorporates a unique, fluid-absorbing matrix
that creates a vapor barrier, protecting the sample
from the exterior environment from evaporation or
hydration and greatly reducing edge effects. The
MicroClime Environmental Lid does not require any
specialized tools and is compatible with robotic plate
lidding and delidding systems.
Increase Microplate Efficiency Up to 37%
MicroClime Lids enable you to use all the wells in your microplate, from edge to center. This can increase your microplate productivity by up to 37%. They also eliminate damaging edge effects which may occur due to long-term cell incubation. They are compatible with a wide variety of SBS-standard microplates.
Minimize edge effects and preserves the concentrations of solutions in microplate wells. MicroClime Lids incorporate a unique, fluid-absorbing matrix. The absorbed fluid creates a vapor barrier that protects the sample from the exterior environment, especially near the edges of the microplate. Compatible with robotic plate lidding systems, and they can be filled with a variety of fluids, using either a hand-held syringe or automated bulk fillers.
MicroClime® Environmental Lid, Introductory Pack of 10 lids
The MicroClime® Environmental Lid minimizes edge
effects and preserves the concentrations of solutions
in microplate wells. The MicroClime® Environmental
Lid incorporates a unique, fluid-absorbing matrix
that creates a vapor barrier, protecting the sample
from the exterior environment from evaporation or
hydration and greatly reducing edge effects. The
MicroClime Environmental Lid does not require any
specialized tools and is compatible with robotic plate
lidding and delidding systems.
Increase Microplate Efficiency Up to 37%
MicroClime Lids enable you to use all the wells in your microplate, from edge to center. This can increase your microplate productivity by up to 37%. They also eliminate damaging edge effects which may occur due to long-term cell incubation. They are compatible with a wide variety of SBS-standard microplates.
Minimize edge effects and preserves the concentrations of solutions in microplate wells. MicroClime Lids incorporate a unique, fluid-absorbing matrix. The absorbed fluid creates a vapor barrier that protects the sample from the exterior environment, especially near the edges of the microplate. Compatible with robotic plate lidding systems, and they can be filled with a variety of fluids, using either a hand-held syringe or automated bulk fillers.
MicroClime® Environmental Lid, Sterile, Introductory Pack of 10 lids
The MicroClime® Environmental Lid minimizes edge
effects and preserves the concentrations of solutions
in microplate wells. The MicroClime® Environmental
Lid incorporates a unique, fluid-absorbing matrix
that creates a vapor barrier, protecting the sample
from the exterior environment from evaporation or
hydration and greatly reducing edge effects. The
MicroClime Environmental Lid does not require any
specialized tools and is compatible with robotic plate
lidding and delidding systems.
Increase Microplate Efficiency Up to 37%
MicroClime Lids enable you to use all the wells in your microplate, from edge to center. This can increase your microplate productivity by up to 37%. They also eliminate damaging edge effects which may occur due to long-term cell incubation. They are compatible with a wide variety of SBS-standard microplates.
Minimize edge effects and preserves the concentrations of solutions in microplate wells. MicroClime Lids incorporate a unique, fluid-absorbing matrix. The absorbed fluid creates a vapor barrier that protects the sample from the exterior environment, especially near the edges of the microplate. Compatible with robotic plate lidding systems, and they can be filled with a variety of fluids, using either a hand-held syringe or automated bulk fillers.
Echo Software Applications
Frequently Used With
Access整合系统
贝克曼库尔特生命科学Access双机器人实验自动化系统是一个紧凑、模块化、高效率和高通量的平台,经过设计和优化,可在样品管理工作流中使用Echo声波移液系统.该实验自动化系统将行业领先的设备和软件与人体工程学和环境管理选项结合在一起,以提供完整、易于使用的、存储到测定的样品管理解决方案.
Access自动化台面整合系统
Access台面操作自动化系统整合革命性声波移液系统Echo、自动板处理系统和其他三方设备,为广泛应用量身定制的无人值守的自动化系统.Access自动化台面整合系统是模块化、灵活的解决方案,可在需要时轻松扩展.
技术文件
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ECHO is a trademark or registered trademark of Labcyte Inc. in the United States and other countries. Labcyte is a Beckman Coulter company. All other trademarks are the property of their respective owners.
