Anti-TCR Cß2 (TRBC2)-APC,SAM.2,50 tests, CE

The TCR constant β chain 2 or TRBC2 is randomly selected during T-cell development in the thymus. TRBC2 is a part of the TCRαβ-CD3 complex, only expressed on mature αβ T-cells; γδ T-cells are inherently negative for TRBC2. TRBC2 is mainly localized on the cell surface but also detectable in the cytoplasm (Horna et al., 2022). Anti-TRBC2 in combination with Anti-TRBC1 conjugates can be used for a low-cost, rapid, and specific T-cell clonality test using flow cytometry. TRBC1 and TRBC2 are mutually exclusive. Normal T-cell populations include a mix of the two, while clonal populations include only one.