DAP12 (DNAX / KARAP / TYROBP) Antibodies

The DAP12 antigen (DNAX activating protein of 12 kDa) is a type I transmembrane glycoprotein which is also known as KARAP (killer cell activating receptor-associated protein) or TYROBP (tyrosine kinase binding protein). It is encoded by a gene located on the chromosome 19q13 and contains an intracytoplasmic immunoreceptor tyrosine-based activation motif (ITAM). The DAP12 antigen associates with a large family of receptors in hematopoietic cells conferring to this antigen a broad range of intracellular signaling functions Interestingly, it has been shown to both potentiate or inhibit leukocytes activation. When associated with KIRs (stimulatory killer Ig-like receptors), the adaptor molecule DAP12 functions as an activation unit leading to the T cell activation. It has also been shown that the activation of the syk/ZAP70 tyrosine kinases by DAP12 plays a role in the stimulation of NK cells and T cells. On the contrary, the DAP12 association with other receptors such as Fc receptor γ-chain and CD3ζ may lead to the regulation of T cell immune response.


Clone: H10E12F4 Isotype: IgG1 Rat

The H10E12F4 monoclonal antibody recognizes monocytes, neutrophils, dendritic cells, NK cells and to a lesser extend basophils, and B lymphocytes. It does not recognize CD4 and CD8 T cells or B cells.

Explore DAP12 Antibodies

Content and Resources

CE-IVD Single Color Antibodies (OUS version) CE-IVD Single Color Antibodies (OUS version)
Single Color Antibodies (OUS version) Single Color Antibodies (OUS version)
Clinical Single Color Antibodies (US version) Clinical Single Color Antibodies (US version)
SuperNova v428: New Bright Polymer Dye for Flow Cytometry Applications In this paper you will discover the latest generation of polymer dyes for flow cytometry applications – SuperNova fluorochromes.
7 Tips for Multi Color Panel Design Seven Tips for Achieving the Perfect Panel for Multicolor Flow Cytometry