CD38(VHH)-Alexa Fluor 700, JK36, 50 tests, CE

The CD38 antigen, also called the T10 antigen, is a single-chain type II transmembranous glycoprotein, the terminal N section of which is cytoplasmic. This glycoprotein with a molecular weight close to 45 kDa is expressed on a large number of hematopoietic cells. The CD38 molecule is expressed by activated T and B cell lymphocytes, monocytes, the majority of NK cells, by medullary thymocytes, and on platelets and red cells. CD38 expression on T cell circulating lymphocytes is weak. Single domain antibodies, constituted by the variable heavy domains of heavy chain antibodies (VHHs), that naturally occur in llamas and other camelids, can overcome these undesired interferences due to their extended foldable complementarity-determining region 3 (CDR3). By virtue of this structural feature, the CD38(VHH) antibody clone JK36 recognizes a cryptic epitope not masked by conventional anti-CD38 therapeutic or analytic antibodies, allowing for uncompromised CD38 detection in the presence of therapeutic antibodies such as Daratumumab.