CD38(VHH)-Alexa Fluor 488, JK36, 50 tests, CE

The CD38 antigen, also called the T10 antigen, is a single-chain type II transmembranous glycoprotein, the terminal N section of which is cytoplasmic. This glycoprotein, with a molecular weight close to 45 kDa, is expressed on a large number of hematopoietic cells. The CD38 molecule is expressed by activated T and B cell lymphocytes, monocytes, the majority of NK cells, by medullary thymocytes, and on platelets and red cells. CD38 expression on T cell circulating lymphocytes is weak. Single-domain antibodies, constituted by the variable heavy domains of heavy-chain antibodies (VHHs), that naturally occur in llamas and other camelids, can overcome these undesired interferences due to their extended, foldable complementarity-determining region 3 (CDR3). By virtue of this structural feature, the CD38 (VHH) antibody clone JK36 recognizes a cryptic epitope not masked by conventional anti-CD38 therapeutic or analytic antibodies, allowing for uncompromised CD38 detection in the presence of therapeutic antibodies such as Daratumumab.