Cell Line Development Products

Cell line development is the process by which the cellular machinery is co-opted to manufacture therapeutic biologics or other proteins of interest. Discover products for this pivotal process below. 


Products for Cell Line Development

Optima XPN ultracentrifuge

Optima Ultracentrifuges

 Our premier line of ultracentrifuges for high quality separations
valitatiter igg quantification assay kit val003

ValitaTiter Assays

 Rapid, high-throughput IgG quantification in crude cell culture samples

CytoFLEX SRT

Simplify your population sorting with the CytoFLEX SRT Cell Sorter

Biomek i-Series Automated Liquid Handlers: Biomek i5 and Biomek i7

Biomek i-Series

Automate every step of the complex Cell Line Development workflow - from transfection to enrichment to limiting dilution to culture/feeding to assaying to hit-picking and expansion.

Echo 525

Acoustic liquid handling for precise and accurate low volume transfers enabling assay miniaturization

Avanti JXN 26 high speed centrifuge

Avanti JXN Series

 High performance centrifugation for cell culture harvest and purification optimization
Vi-CELL MetaFLEX bioanalyte analyzer evaluates pH, pO2, pCO2, glucose, lactate, electrolytes and more

Vi-CELL MetaFLEX

 Use the Vi-CELL MetaFLEX for fast bioreactor media analysis

Vi-CELL BLU

Used at multiple steps along cell line development. Eliminate human error and user bias when counting cells and determining viability.

Avanti J-15R benchtop centrifuge

Avanti J-15R

Separate cells from culture media for antibody titer assays, quantification. Pellet cells for media exchanges.

Helpful Links

Content and Resources

Method for Determining Cell Type Parameter Adjustment to Match Legacy Vi CELL XR This application note details how you can use the plate loader feature on the Vi-CELL BLU to match cell types to give cell counts and viability levels equivalent to those obtained on existing Vi-CELL XR instruments.
Considerations of Cell Counting Analysis when using Different Types of Cells This paper reviews several different cell types and cell preparation approaches using standard cells, such as, CHO cells, EL4 cells, SF9 cells, and HELA cell cultures.
Cell Line Development Traditionally, cell line development has been achieved manually, limiting it to low-throughput applications and making it susceptible to variability caused by human error and contamination. Automating the cell line development workflow— from a point of genetic manipulation through clone selection—increases throughput and optimizes media conditions which are critical for cell lines needed for vaccines, antibody production, recombinant therapies and drug screening.
Automating Cell Line Development for Biologics Cell line development is a highly-involved, multi-week workflow that involves the plating, screening, and expansion of single cell-derived clones to establish a protein-expression cell line. This complex process required significant throughput of sterile cell manipulations, long-term incubations, centrifugation, cell counting, monoclonality determination and growth tracking, and protein production assessment.
Cell-Line Engeneering Bioproduction is a booming industry, with more therapeutics being produced in cell culture than ever before. With increased workflow flexibility, decreased variability, and high product yields, cell-line engineering is here to stay. But before you take your bioproduction to the next level, you’ll need to know a bit more about your product, your cells, and their health. It’s time for a cell-line engineering check-up